Networks and Spatial Economics (NETS) is devoted to the mathematical and numerical study of economic activities facilitated by human infrastructure, broadly defined to include technologies pertinent to information, telecommunications, the Internet, transportation, energy storage and transmission, and water resources. Because the spatial organization of infrastructure most generally takes the form of networks, the journal encourages submissions that employ a network perspective. However, non-network continuum models are also recognized as an important tradition that has provided great insight into spatial economic phenomena; consequently, the journal welcomes with equal enthusiasm submissions based on continuum models.

The journal welcomes the full spectrum of high quality work in networks and spatial economics including theoretical studies, case studies and algorithmic investigations, as well as manuscripts that combine these aspects. Although not devoted exclusively to theoretical studies, the journal is "theory-friendly". That is, well thought out theoretical analyses of important network and spatial economic problems will be considered without bias even if they do not include case studies or numerical examples.